2-(2-chlorophenyl)- 1-(1-pentylindol-3-yl) ethanone

JWH 203 is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid (CB) agonist with Ki values of 8.0 and 7.0 nM at the CB1and CB2 receptors, respectively.1 Similar to the related 2′-methoxy compound JWH 250, JWH 203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole CB compounds. Compared to JWH 250, JWH 203 displays slightly more potent binding affinities for the CB1 and CB2receptors (JWH 250 Kis = 11 and 33 nM, respectively).1